EPIGENETICALLY MODULATED MIR-1224 SUPPRESSES THE PROLIFERATION OF HCC THROUGH CREB-MEDIATED ACTIVATION OF YAP SIGNALING PATHWAY

Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway

Mounting evidence has demonstrated that microRNA-1224 (miR-1224) is commonly downregulated and serves as a tumor suppressor in multiple malignancies.However, the role and mechanisms responsible for miR-1224 in hepatocellular carcinoma (HCC) remain unclear.In this study, we found that the expression of miR-1224 was downregulated in HCC.Low miR-1224

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Aerosol optical property measurement using the orbiting high-spectral-resolution lidar on board the DQ-1 satellite: retrieval and validation

The Atmospheric Environment Monitoring Satellite (AEMS), also called Daqi-1 or DQ-1, was launched in April 2022; one of its main payloads is a high-spectral-resolution lidar (HSRL) system.This new system enables the accurate measurements of global aerosol optical properties, which can be used in the geoscientific community after the retirement of t

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Symptom frequency and development of a generic functional disorder symptom scale suitable for use in studies of patients with irritable bowel syndrome, fibromyalgia syndrome or chronic fatigue syndrome

Objectives: To describe the extent to which irritable bowel syndrome (IBS), fibromyalgia syndrome (FMS), and chronic fatigue syndrome (CFS) exhibit symptom overlap, and to validate a patient-derived, generic symptom questionnaire.Methods: A patient-derived 61-item symptom-frequency questionnaire was completed by participants recruited through IBS,

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Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria

Abstract The non-filarial and non-communicable disease podoconiosis affects around 4 million people and is characterized by severe leg lymphedema accompanied with painful intermittent acute inflammatory episodes, called acute dermatolymphangioadenitis (ADLA) attacks.Risk factors have Blush Palette been associated with the disease but the mechanisms

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